Invitrogen™ UGT1A1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547844

Catalog No. PIPA547844

Description

Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Specifications

• Antigen: UGT1A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UGT1A1
• Gene Alias: B1; BILIQTL1; bilirubin UDP-glucuronosyltranserase; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; bilirubin-specific UDPGT isozyme 1; EC 2.4.1.17; GNT1; HUG BR1; HUGBR1; hUG-BR1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glucuronosyltransferase family 1 member A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1 family member 1; UDP-glucuronosyltransferase 1 family, member 1; UDP-glucuronosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; UDPGT; UDPGT 1-1; Udpgt-1a; UGT 1A; UGT1; UGT1 01; UGT1*1; UGT1.1; UGT1-01; UGT1A; UGT-1A; UGT1A01; UGT1A1; UGTBR1
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54658
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P22309
• Gene Symbols: UGT1A1
• Immunogen: E. coli-derived recombinant human Glucuronosyltransferase 1A1/UGT1A1 Leu60-Thr168.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov