Invitrogen™ UGT1A6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA542009

Catalog No. PIPA542009

Description

Peptide sequence: APHLRPAAHD LTWYQYHSLD VIGFLLAVVL TVAFITFKCC AYGYRKCLGK Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 93%; Zebrafish: 92%.

UGT1A6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.

Specifications

• Antigen: UGT1A6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UGT1A6
• Gene Alias: A1; GNT1; HLUGP; HLUGP1; MGC29860; Phenol UDP-glucuronosyltransferase; phenol-metabolizing UDP-glucuronosyltransferase; P-nitrophenol specific; P-nitrophenol-specific UDPGT; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glucuronosyltransferase 1 family, polypeptide A6A; UDP glucuronosyltransferase 1A6; UDP glucuronosyltransferase family 1 member A6; UDP glycosyltransferase 1 family polypeptide A4; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1A6; UDP-glucuronosyltransferase 1-F; Udpgt; UDPGT 1-6; UGP1A1; UGT1; UGT1*6; UGT1.6; UGT1-06; Ugt1a6; Ugt1a6a; UGT1A6S; UGT1A7; UGT1F; UGT-1F
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54578
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: P19224
• Gene Symbols: UGT1A6
• Immunogen: Synthetic peptide directed towards the C-terminal of human UGT1A6 (aa 470-519).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov