Invitrogen™ UHRF2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596110

Catalog No. PIPA596110

Description

Positive Samples: Jurkat, U-87MG, HeLa, Mouse liver, Rat thymus; Cellular Location: Nucleus Immunogen sequence: DSSLPSTSKQ NDAQVKPSSH NPPKVKKTAR GGSSSQPSTS ARTCLIDPGF GLYKVNELVD ARDVGLGAWF EAHIHSVTRA SDGHSRGKTP LKNGSSYKRT NGNVNHNSKE NTNKLDNVPS TSNSDSVAAD EDVIYHIEYD EYPESGILEM NVKDLRPRAR TILKWNELNV GDVVMVNYNV ENPGKRGFWY DAEITTLKTI SRTKKEVRVK VFLGGSEGTL NDCRVMSVDE IFKIEKPGAH PISFADGKFL RKNDPECDLC GGDPDKTCHM CSCHKCGEKR DPNM.

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.

Specifications

• Antigen: UHRF2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UHRF2
• Gene Alias: 2310065A22Rik; AI426270; AW214556; D130071B19Rik; E3 ubiquitin-protein ligase UHRF2; Nirf; np95/ICBP90-like RING finger protein; Np95-like ring finger protein; Nuclear protein 97; nuclear zinc finger protein Np97; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF2; RNF107; RP11-472F14.2; TDRD23; ubiquitin like with PHD and ring finger domains 2; ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin-like, containing PHD and RING finger domains 2; ubiquitin-like, containing PHD and RING finger domains, 2; ubiquitin-like-containing PHD and RING finger domains protein 2; UHRF2; URF2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 109113, 115426, 309331
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.58 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q7TMI3, Q96PU4
• Gene Symbols: UHRF2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 76-359 of mouse Uhrf2 (NP_6591222).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov