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Invitrogen™ UL13_HHV11 Polyclonal Antibody
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Catalog No. PIPA567985
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PIPA567985 100 μL
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Catalog No. PIPA567985 Supplier Invitrogen™ Supplier No. PA567985
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Description

Rabbit Polyclonal Antibody

UL13_HHV11 Polyclonal Antibody for Western Blot

UL13 is a multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and regulation of viral and cellular gene expression. Regulates the nuclear localization of viral envelopment factors UL34 and UL31, by phosphorylating the US3 kinase, indicating a role in nuclear egress. Disrupts host nuclear lamins, including LMNA and LMNB1. Phosphorylates the viral Fc receptor composed of glycoproteins E (gE) and I (gI). Phosphorylation of glycoprotein E (gE) by UL13 alters its subcellular localization, from the host early endosome to the plasma membrane. Participates in the transcriptional regulation of cellular and viral mRNAs mainly by phosphorylating the viral transcriptional regulator ICP22. Additional substrates have been identified, including UL41, UL49 or host EF1D.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UL13_HHV11
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Host Species Rabbit
Immunogen Synthesized peptide derived from human UL13_HHV11.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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