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Invitrogen™ ULBP1 Polyclonal Antibody
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Catalog No. PIPA547131
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100 μg
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PIPA547131 100 μg
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Catalog No. PIPA547131 Supplier Invitrogen™ Supplier No. PA547131
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Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human (rh) ULBP-2 and rhULBP-3 is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ULBP1
Applications Neutralization, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene ULBP1
Gene Accession No. Q9BZM6
Gene Alias A430108B07Rik; ALCAN-beta; MULT1; N2DL1; N2DL-1; NKG2D ligand; NKG2D ligand 1; NKG2D ligand1; NKG2DL1; RAET1I; retinoic acid early transcript 1I; UL16 binding protein 1; UL16-binding protein 1; UL16-binding protein-like transcript 1; ULBP; ULBP 1; ULBP1
Gene Symbols ULBP1
Host Species Goat
Immunogen Sf 21-derived recombinant human ULBP-1 Gly26-Pro215.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80329
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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