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Invitrogen™ ULK1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA577810
Description
A 1:1,000 dilution of PA5-77810 was sufficient for detection of ULK1 in 15 μg of Human HeLa Cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. Detects approximately 100 kDa.
ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
Specifications
ULK1 | |
Polyclonal | |
Unconjugated | |
ULK1 | |
APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; ATG1A; AU041434; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; hATG1; KIAA0722; mKIAA0722; Serine/threonine-protein kinase ULK1; serine/threonine-protein kinase Unc51.1; ULK 1; Ulk1; UNC 51; UNC51; unc-51 like autophagy activating kinase 1; unc-51 like kinase 1; Unc51.1; unc-51-like kinase 1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
22241, 360827, 8408 | |
-20°C | |
Liquid |
Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 50% glycerol and 0.09% sodium azide; pH 7.4 | |
O70405, O75385 | |
ULK1 | |
Synthetic peptide from the mid-protein of Human ULK1 (aa 567-577). | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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