Invitrogen™ ULK3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA559193

Catalog No. PIPA559193

Description

Immunogen sequence: ILKGIRHPHI VQLKDFQWDS DNIYLIMEFC AGGDLSRFIH TRRILPEKVA RVFMQQLASA LQFLHERNIS HLDLKPQNIL LSSLEKPHLK LADFGFAQHM SPWDEKHVLR GSPLYMAPEM VCQRQYDARV DLWSMGVILY GETSFPC Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

ULK3 or unc-51-like kinase 3 is a member of the serine/threonine kinase family that is involved in the SHH signaling pathway as a positive regulator of GLI proteins. ULK3 enhances endogenous and over-expressed GLI transcriptional activity in cultured cells and alters its subcellular localization. Furthermore, ULK3 phosphorylates GLI proteins in vitro. ULK3 is widely expressed and its expression is higher in a number of tissues where SHH signaling is known to be active, again suggesting that ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins.

Specifications

• Antigen: ULK3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ULK3
• Gene Alias: 1200015E14Rik; DKFZP434C131; EC:2.7.11.1; FLJ90566; Serine/threonine-protein kinase ULK3; ULK3; unc-51 like kinase 3; unc-51-like kinase 3
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25989, 691171, 71742
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: D3ZHP7, Q3U3Q1, Q6PHR2
• Gene Symbols: ULK3
• Immunogen: Recombinant protein corresponding to Human ULK3. Recombinant protein control fragment (Product #RP-89789).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG