Tocris Bioscience UNC 1999
Potent and selective EZH2/EZH1 inhibitor
Manufacturer: Tocris Bioscience 4904/10
DescriptionPotent and SAM-competitive EZH2/EZH1 lysine methyltransferase inhibitor (IC50 values are 10 and 45 nM, respectively). Selective for EZH2/EZH1 over a panel of other methyltransferases and non-epigenetic targets. Reduces H3K27me3 levels in vitro. Prolongs survival of MLL-AF9 bearing mice. Orally bioavailable.
Negative Control also available.
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