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Tocris Bioscience™ UNC 1999 Available on GSA/VA Contract for Federal Government customers only.

Potent and selective EZH2/EZH1 inhibitor

Manufacturer:  Tocris Bioscience™ 4904/10

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Catalog No. 49-041-0


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Description

Description

Potent and SAM-competitive EZH2/EZH1 lysine methyltransferase inhibitor (IC50 values are 10 and 45 nM, respectively). Selective for EZH2/EZH1 over a panel of other methyltransferases and non-epigenetic targets. Reduces H3K27me3 levels in vitro. Prolongs survival of MLL-AF9 bearing mice. Orally bioavailable.

Negative Control also available.

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