Tocris Bioscience™ UNC 6852

Description

Polycomb repressive complex 2 (PRC2) Degrader PROTAC™

UNC 6852 is a polycomb repressive complex 2 (PRC2) Degrader (PROTAC™; DC50 = 0.79 μM). It comprises an EED (embryonic ectoderm development) based ligand, joined by a linker to a von Hippel-Lindau ligand. In B lymphoblast cell lines, UNC 6852 selectively degrades PRC2 components EED (DC50 = 0.31 μM, Dmax = 94%), enhancer of zeste homolog 2 (EZH2, DC50 = 0.67 μM, Dmax = 96%), and suppressor of zeste homolog 12 (SUZ12, DC50 = 0.59 μM, Dmax = 82%). In zebrafish, UNC 6852 treatment increases transcription of tfpia and prolongs time to occlusion (TTO) in the caudal vein following laser injury.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

• Chemical Name or Material: (2 S,4 R)-1-(-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4 ]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
• CAS: 2688842-08-0
• Quantity: 5 mg
• Target: Active Degraders
• Molecular Formula: C₄₃H₄₈N₁₀O₆S
• Purity: 0.98