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Tocris Bioscience™ UNC 8732

Catalog No. 81185
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Catalog No. Quantity
81-185 5 mg
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Catalog No. 81-185 Supplier Tocris Bioscience™ Supplier No. 8118/5
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Description

Potent NSD2 Degrader

UNC 8732 is a potent nuclear receptor binding SET domain-containing 2 (NSD2) Degrader (DC50 = 60 nM; Dmax = 97%). NSD2 degradation is driven by the aldehyde metabolite of UNC 8732 in vitro. Recruits FBX022 and SCF complexes for degradation to reduce H3K36me2 levels in cells. Reduces viability and restores glucocorticoid sensitivity of NSD2 p.E1099K mutant ALL cells.

Specifications

Chemical Name or Material N-[[4-[[[2-(6-Amino-1-oxohexyl)-1,2,3,4-tetrahydro-6-isoquinolinyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-7-carboxamide trifluoroacetate
CAS 2929304-06-1
Quantity 5 mg
Target Active Degraders
Molecular Formula C35H39N5O5.CF3CO2H
Purity 0.98
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