Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

UNC13D/Munc 13-4 Rabbit anti-Human, Mouse, Clone: 1224B, R&D Systems™

Recombinant Monoclonal Antibody

$125.35 - $329.00

Specifications

Antigen UNC13D/Munc 13-4
Formulation Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with Sodium Azide
Format Purified
Clone 1224B
Applications Western Blot
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MAB89662SP View Documents R&D Systems
MAB89662SP
25 ug Each for $125.35
Add to cart
 
MAB89662100 View Documents R&D Systems
MAB89662100
100 ug Each for $329.00
Add to cart
 
Description

Description

UNC13D (also Munc13-4) is a 123kDa cytoplasmic and peripheral membrane protein that is expressed at highest levels in hematopoietic tissues. UNC13D appears to play a role in vesicle maturation during exocytosis and its expression is obligatory for exocytosis of cytolytic granules from NK and T cells. A point mutation in intron 1 of UNC13D causes familial hematophagocytic lymphohistiocytosis type3, a rare autosomal recessive immune deficiency. The mutation disrupts transcription factor binding and prevents expression of an alternative isoform that is required for lymphocyte cytotoxicity. The conventional and alternative isoforms are identical from amino acids (aa) 40-1090 but have distinct N-terminal segments. Human and mouse have 75% aa sequence identity throughout the region used as the immunogen. It is unknown whether mice express the alternative isoform.
Specifications

Specifications

UNC13D/Munc 13-4
Purified
Western Blot
Rabbit
Protein A or G purified from cell culture supernatant
RUO
Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with Sodium Azide
1224B
Unconjugated
IgG
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit