UNC13D/Munc 13-4 Rabbit anti-Human, Mouse, Clone: 1224B, R&D Systems™

Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
MAB89662SP	R&D Systems MAB89662SP	25 ug
MAB89662100	R&D Systems MAB89662100	100 ug

Description

UNC13D (also Munc13-4) is a 123kDa cytoplasmic and peripheral membrane protein that is expressed at highest levels in hematopoietic tissues. UNC13D appears to play a role in vesicle maturation during exocytosis and its expression is obligatory for exocytosis of cytolytic granules from NK and T cells. A point mutation in intron 1 of UNC13D causes familial hematophagocytic lymphohistiocytosis type3, a rare autosomal recessive immune deficiency. The mutation disrupts transcription factor binding and prevents expression of an alternative isoform that is required for lymphocyte cytotoxicity. The conventional and alternative isoforms are identical from amino acids (aa) 40-1090 but have distinct N-terminal segments. Human and mouse have 75% aa sequence identity throughout the region used as the immunogen. It is unknown whether mice express the alternative isoform.

Specifications

• Antigen: UNC13D/Munc 13-4
• Format: Purified
• Applications: Western Blot
• Host Species: Rabbit
• Purification Method: Protein A or G purified from cell culture supernatant
• Regulatory Status: RUO

• Formulation: Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with Sodium Azide
• Clone: 1224B
• Conjugate: Unconjugated
• Isotype: IgG
• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.