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Invitrogen™ UNC5A Polyclonal Antibody
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Catalog No. PIPA547133
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100 μg
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PIPA547133 100 μg
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Catalog No. PIPA547133 Supplier Invitrogen™ Supplier No. PA547133
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Description

Goat Polyclonal Antibody

In Western blots, less than 5% cross-reactivity with recombinant rat UNC5H2, recombinant human (rh) UNC5H3 and rhUNC5H4 is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain, UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UNC5A
Applications Neutralization, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Unc5a
Gene Accession No. O08721
Gene Alias Kiaa1976; mKIAA1976; netrin receptor UNC5A; netrin receptor Unc5h1; protein unc-5 homolog 1; Protein unc-5 homolog A; transmembrane receptor Unc5H1; unc5 (C.elegans homolog) a; unc5 homolog 1; unc-5 homolog 1; unc-5 homolog A; unc-5 homolog A (C. elegans); unc-5 netrin receptor A; UNC5A; Unc5h1; UNC5H1FLJ16449
Gene Symbols Unc5a
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant rat UNC5H1 Gln26-Asp358.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60629
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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