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Invitrogen™ UNC5A Polyclonal Antibody
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Catalog No. PIPA5103957
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PIPA5103957 100 μL
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Catalog No. PIPA5103957 Supplier Invitrogen™ Supplier No. PA5103957
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total UNC5A.

The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain, UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UNC5A
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Unc5a
Gene Accession No. O08721, Q6ZN44, Q8K1S4
Gene Alias Kiaa1976; mKIAA1976; netrin receptor UNC5A; netrin receptor Unc5h1; protein unc-5 homolog 1; Protein unc-5 homolog A; transmembrane receptor Unc5H1; unc5 (C.elegans homolog) a; unc5 homolog 1; unc-5 homolog 1; unc-5 homolog A; unc-5 homolog A (C. elegans); unc-5 netrin receptor A; UNC5A; Unc5h1; UNC5H1FLJ16449
Gene Symbols Unc5a
Host Species Rabbit
Immunogen A synthesized peptide derived from human UNC5A(Accession Q6ZN44), corresponding to amino acid residues S356-G406.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 107448, 60629, 90249
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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