Invitrogen™ UNC5B Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA537993

Catalog No. PIPA537993

Description

This antibody is predicted to react with mouse, rat, dog, pig and cow based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.

Specifications

• Antigen: UNC5B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UNC5B
• Gene Alias: 6330415E02Rik; A630020F16; C. elegans; D10Bwg0792e; Netrin receptor UNC5B; p53RDL1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; unc5 homolog 2; unc-5 homolog 2; unc-5 homolog B; unc-5 homolog B (C. elegans); unc-5 netrin receptor B; Unc5b; UNC5H2; UNQ1883/PRO4326
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 219699
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8IZJ1
• Gene Symbols: UNC5B
• Immunogen: Peptide with sequence C-SARDWIFQLKTQAHQ, from the internal region of UNC5B (aa629-643).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG