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Invitrogen™ UNC5B Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5116108
Description
Antibody detects endogenous levels of total UNC5B.
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
Specifications
UNC5B | |
Polyclonal | |
Unconjugated | |
UNC5B | |
6330415E02Rik; A630020F16; C. elegans; D10Bwg0792e; Netrin receptor UNC5B; p53RDL1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; unc5 homolog 2; unc-5 homolog 2; unc-5 homolog B; unc-5 homolog B (C. elegans); unc-5 netrin receptor B; Unc5b; UNC5H2; UNQ1883/PRO4326 | |
Rabbit | |
Affinity chromatography | |
RUO | |
107449, 219699, 60630 | |
-20°C | |
Liquid |
Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide | |
O08722, Q8IZJ1, Q8K1S3 | |
UNC5B | |
A synthesized peptide derived from human UNC5B(Accession Q8IZJ1), corresponding to amino acid residues V387-L437. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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