Invitrogen™ UNC5B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116108

Catalog No. PIPA5116108

Description

Antibody detects endogenous levels of total UNC5B.

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.

Specifications

• Antigen: UNC5B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UNC5B
• Gene Alias: 6330415E02Rik; A630020F16; C. elegans; D10Bwg0792e; Netrin receptor UNC5B; p53RDL1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; unc5 homolog 2; unc-5 homolog 2; unc-5 homolog B; unc-5 homolog B (C. elegans); unc-5 netrin receptor B; Unc5b; UNC5H2; UNQ1883/PRO4326
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 107449, 219699, 60630
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O08722, Q8IZJ1, Q8K1S3
• Gene Symbols: UNC5B
• Immunogen: A synthesized peptide derived from human UNC5B(Accession Q8IZJ1), corresponding to amino acid residues V387-L437.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov