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Invitrogen™ UNC5B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116108

Catalog No. PIPA5116108


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Description

Description

Antibody detects endogenous levels of total UNC5B.

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

UNC5B
Polyclonal
Unconjugated
UNC5B
6330415E02Rik; A630020F16; C. elegans; D10Bwg0792e; Netrin receptor UNC5B; p53RDL1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; unc5 homolog 2; unc-5 homolog 2; unc-5 homolog B; unc-5 homolog B (C. elegans); unc-5 netrin receptor B; Unc5b; UNC5H2; UNQ1883/PRO4326
Rabbit
Affinity chromatography
RUO
107449, 219699, 60630
-20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide
O08722, Q8IZJ1, Q8K1S3
UNC5B
A synthesized peptide derived from human UNC5B(Accession Q8IZJ1), corresponding to amino acid residues V387-L437.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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