Invitrogen™ UNC5CL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530917

Catalog No. PIPA530917

Description

Recommended positive controls: Raji. Predicted reactivity: Human (99%), Mouse (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

UNC5CL is a membrane protein belonging to theUNC-5 family with a death domain and a ZU5 domain and is known to interact with p65/RELA and NFKB1. UNC5CL is known to interact with subunit p105 of NF-kappaB and transactivator p65 and is thus involved in inhibition of NF-kappaB activation and NF-kappaB-dependent transcription by inhibiting the binding of NF-kappaB to its target sequence (providing an alternative regulatory mechanism for NF-kappaB-mediated transcription). This regulatory protein sensitizes cells to apoptosis induced by TNF and TRAIL.

Specifications

• Antigen: UNC5CL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UNC5CL
• Gene Alias: 2510009H09Rik; BB155270; MGC34763; MUXA; OTTHUMP00000016362; protein unc-5 homolog C-like; unc-5 family C-terminal like; unc-5 homolog C (C. elegans)-like; UNC5CL; UNC5C-like protein; zu-5; ZU5 and death domain containing; ZU5 and death domain-containing inhibitor of NF-kB; ZU5 and death domain-containing protein; ZUD
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 222643
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8IV45
• Gene Symbols: UNC5CL
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 302 and 483 of Human UNC5CL.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov