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Invitrogen™ UNC93B1 Polyclonal Antibody
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Catalog No. PIPA523196
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100 μg
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Catalog No. Quantity
PIPA523196 100 μg
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Catalog No. PIPA523196 Supplier Invitrogen™ Supplier No. PA523196
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Description

Rabbit Polyclonal Antibody

UNC93B1 Polyclonal Antibody for Western Blot

The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UNC93B1
Applications Western Blot
Classification Polyclonal
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene UNC93B1
Gene Accession No. Q8VCW4, Q9H1C4
Gene Alias hUNC93B1; IIAE1; Protein unc-93 homolog B1; UNC93; unc93 homolog B; unc-93 homolog B; unc93 homolog B1; unc-93 homolog B1 (C. elegans); unc-93 related protein; UNC93B; Unc93b1; Unc-93B1
Gene Symbols UNC93B1
Host Species Rabbit
Immunogen A portion of amino acid 500-550 of mouse UNC93B protein.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361689, 54445, 81622
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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