Invitrogen™ UNC93B1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583437

Catalog No. PIPA583437

Description

Immunogen sequence: NYITRMAQKY HEYSHYKEQD GQGMKQRPPR GSHAPY.

The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.

Specifications

• Antigen: UNC93B1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UNC93B1
• Gene Alias: hUNC93B1; IIAE1; Protein unc-93 homolog B1; UNC93; unc93 homolog B; unc-93 homolog B; unc93 homolog B1; unc-93 homolog B1 (C. elegans); unc-93 related protein; UNC93B; Unc93b1; Unc-93B1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 81622
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H1C4
• Gene Symbols: UNC93B1
• Immunogen: Recombinant protein corresponding to Human UNC93B1. Recombinant protein control fragment (Product #RP-104695).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov