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Invitrogen™ UNC93B1 Polyclonal Antibody
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Catalog No. PIPA590319
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100 μL
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PIPA590319 100 μL
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Catalog No. PIPA590319 Supplier Invitrogen™ Supplier No. PA590319
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KTGLSTLLGI LYEDKERQDF IFTIYHWWQA VAIFTVYLGS SLHMKAKLAV LLVTLVAAAV SYLRMEQKLR RGVAPRQPRI PRPQHKVRGY RYLEEDNSDE S; Positive Samples: 293T, HeLa, Mouse kidney, Mouse lung, Mouse spleen, Rat kidney, Rat lung, Rat spleen; Cellular Location: Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Multi-pass membrane protein, phagosome.

The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UNC93B1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene UNC93B1
Gene Accession No. Q8VCW4, Q9H1C4
Gene Alias hUNC93B1; IIAE1; Protein unc-93 homolog B1; UNC93; unc93 homolog B; unc-93 homolog B; unc93 homolog B1; unc-93 homolog B1 (C. elegans); unc-93 related protein; UNC93B; Unc93b1; Unc-93B1
Gene Symbols UNC93B1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 450-550 of human UNC93B1 (NP_1121922).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361689, 54445, 81622
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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