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UNG Mouse anti-Human, Non-human primate, Clone: OTI1G2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525737

Catalog No. PIMA525737


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Description

Description

The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These forms are generated by alternative splicing and the use of two differentially regulated promoters, PA and PB (Slupphaug et al., 1993; Nilsen et al., 1997) The cDNAs for UNG1 and UNG2 are of similar size (2061 and 2058 bp, respectively) and as a result the corresponding mRNAs are not resolved as two species in gel electrophoresis (Huag et al., 1998). Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids of the N-terminal sequence that is not necessary for catalytic activity. A major role of the UNG gene products is to repair mutagenic U:G mispairs caused by cytosine deamination. For example, UNG2 removes misincorporated dUMP residues. The level and expression pattern of UNG1 and UNG2 differs between cell and tissue type (Huag et al. 1998). Additionally, the expression of UNG is cell cycle regulated (Nagelhus et al. 1995). The expression and activity of UNG has been found in general to be higher in proliferating as compared to nonproliferating tissues and cells (reviewed in Kruman et al. 2004). UNG1 is a 304 amino acid protein. UNG2 is a 313 amino acid protein.
Specifications

Specifications

UNG
Monoclonal
0.3 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P13051
DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2, uracil-DNA glycosylase 1, uracil-DNA glycosylase 2
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
706816, 7374
Immunohistochemistry (Paraffin), Western Blot
OTI1G2
Unconjugated
UNG
Liquid
UNG
Full length human recombit protein of UNG produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Non-human primate
Documents
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