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Invitrogen™ UNG2 Polyclonal Antibody
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Catalog No. PIPA534551
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100 μg
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Catalog No. Quantity
PIPA534551 100 μg
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Catalog No. PIPA534551 Supplier Invitrogen™ Supplier No. PA534551
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Description

Rabbit Polyclonal Antibody

A suggested positive control is NIH-3T3 cell lysate. PA5-34551 can be used with blocking peptide PEP-1594.

The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promoters and alternative splicing. UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from DNA that arise through either misincorporation during replication or cytosine deamination. UNG2 can also be bound by the HIV-1 integrase and incorporated into the virion particle, suggesting that it is required to remove uracils from the viral genome. As the intrinsic antiviral protein APOBEC3G generates numerous uracils in the HIV genome during its replication, it may be that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the viral genome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UNG2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene UNG
Gene Accession No. P13051, P97931
Gene Alias DGU; HIGM4; HIGM5; UDG; UDG2; Ung; Ung1; UNG15; UNG2; uracil DNA glycosylase; uracil-DNA glycosylase; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2; uracil-DNA glycosylase nuclear isoform
Gene Symbols UNG
Host Species Rabbit
Immunogen A 17 amino acid peptide near the amino terminus of human UNG2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22256, 7374
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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