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Unrip Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS5132R

Catalog No. 50-198-6355


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Description

Description

STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
Specifications

Specifications

Unrip
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Strap
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
11171
Strap
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Q9Y3F4
AW557906; BOS_5794; C78091; C79202; MAP activator with WD repeats; MAWD; PT-WD; serine/threonine kinase receptor associated protein; Serine-threonine kinase receptor-associated protein; STRAP; UNR-interacting protein; UNRIP; WD-40 repeat protein PT-WD
KLH conjugated synthetic peptide derived from human Unrip.
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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