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uPA Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 179681AP

Catalog No. 50-173-1905


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Description

Description

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer ft.s disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

uPA
0.29 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P00749, P06869, P29598
ATF, PLAU, U plasminogen activator, uPA, URK
Rabbit
IgG
150 μL
-20°C
Primary
18792, 25619, 5328
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
PLAU
Liquid
Plau
uPA Fusion Protein Ag11813
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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