Invitrogen™ uPAR Monoclonal Antibody (109801)

Catalog No.	Quantity
PIMA523853	100 μg

Catalog No. PIMA523853 Supplier Invitrogen™ Supplier No. MA523853

Description

Rat Monoclonal Antibody

In Western blots, this antibody does not cross-react with recombinant human uPAR. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue. Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer. UPAR appears to be a useful prognostic marker for advanced endometrial cancer.

Specifications

• Antigen: uPAR
• Applications: Flow Cytometry, Neutralization, Western Blot
• Classification: Monoclonal
• Clone: 109801
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: PLAUR
• Gene Accession No.: P35456
• Gene Alias: Cd87; MO3; Monocyte activation antigen Mo3; Par; plasminogen activator urokinase receptor 3; plasminogen activator, urokinase receptor; PLAUR; Plaur3; sCD87; soluble CD87; uPAR; U-PAR; uPAR-2; uPAR-3; u-plasminogen activator receptor form 2; urinary plasminogen activator receptor 2; urinary plasminogen activator receptor 3; URKR; urokinase plasminogen activator receptor; urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor; urokinase-type plasminogen activator receptor
• Gene Symbols: PLAUR
• Host Species: Rat
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse uPAR isoform 1 Leu24-Thr297.
• Purification Method: Protein A/G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18793
• Target Species: Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2a