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Invitrogen™ uPAR Monoclonal Antibody (A6E7)
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Catalog No. FEMA550590
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100 μL
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FEMA550590 100 μL
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Catalog No. FEMA550590 Supplier Invitrogen™ Supplier No. MA550590
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Description

Mouse Monoclonal Antibody

Positive control: U937 cell lysate, U937 cell lysate treated with 200 nM PMA for 72 hours. Predicted band size: 36 kDa Subcellular Location: Cell membrane, invadopodium membrane; Secreted.

The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue. Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer. UPAR appears to be a useful prognostic marker for advanced endometrial cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen uPAR
Applications Western Blot
Classification Monoclonal
Clone A6E7
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene PLAUR
Gene Accession No. Q03405
Gene Alias Cd87; MO3; Monocyte activation antigen Mo3; Par; plasminogen activator urokinase receptor 3; plasminogen activator, urokinase receptor; PLAUR; Plaur3; sCD87; soluble CD87; uPAR; U-PAR; uPAR-2; uPAR-3; u-plasminogen activator receptor form 2; urinary plasminogen activator receptor 2; urinary plasminogen activator receptor 3; URKR; urokinase plasminogen activator receptor; urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor; urokinase-type plasminogen activator receptor
Gene Symbols PLAUR
Host Species Mouse
Immunogen Recombinant protein within human uPA Receptor aa 51-250/335.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5329
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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