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Invitrogen™ UPF1 Polyclonal Antibody
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Catalog No. PIPA590296
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100 μL
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PIPA590296 100 μL
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Catalog No. PIPA590296 Supplier Invitrogen™ Supplier No. PA590296
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Description

Rabbit Polyclonal Antibody

Positive Samples: 293T, SH-SY5Y, K-562, HL-60, Mouse liver; Cellular Location: Cytoplasm, Nucleus, P-body Immunogen sequence: QEVEIASVDA FQGREKDFII LSCVRANEHQ GIGFLNDPRR LNVALTRARY GVIIVGNPKA LSKQPLWNHL LNYYKEQKVL VEGPLNNLRE SLMQFSKPRK LVNTINPGAR FMTTAMYDAR EAIIPGSVYD RSSQGRPSSM YFQTHDQIGM ISAGPSHVAA MNIPIPFNLV MPPMPPPGYF GQANGPAAGR GTPKGKTGRG GRQKNRFGLP GPSQTNLPNS QASQDVASQP FSQGALTQGY ISMSQPSQMS QPGLSQPELS QDSYLGDEFK SQIDVALSQD STYQGERAYQ HGGVTGLSQY.

Upf1 was identified as an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codons. Upf1 was found to be an ATP-dependent RNA helicase in the cytoplasm and was later shown to be a component of cytoplasmic P-bodies. Upf1 phosphorylation mediates the repression of translation that accompanies NMD, allowing mRNA accessibility to the NMD machinery. Two other active components of NMD, Upf2 and Upf3, were also identified and described as having perinuclear and nucleocytoplasmic localization, respectively.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UPF1
Applications ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.85 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene UPF1
Gene Accession No. Q92900, Q9EPU0
Gene Alias ATP-dependent helicase RENT1; B430202H16Rik; delta helicase; FLJ43809; FLJ46894; HUPF1; KIAA0221; LOW QUALITY PROTEIN: regulator of nonsense transcripts 1; mUpf1; Nonsense mRNA reducing factor 1; NORF1; pNORF1; PNORF-1; Regulator of nonsense transcripts 1; Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog); Rent1; smg-2; smg-2 homolog, nonsense mediated mRNA decay factor; Upf1; UPF1 regulator of nonsense transcripts homolog; UPF1 regulator of nonsense transcripts homolog (yeast); UPF1 RNA helicase and ATPase; UPF1, RNA helicase and ATPase; Upflp; up-frameshift mutation 1 homolog; up-frameshift suppressor 1 homolog; wu:fi40f07; wu:fj48a01; yeast Upf1p homolog; zgc:55472
Gene Symbols UPF1
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19704, 5976, 684558
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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