Invitrogen™ UPF2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596574

Catalog No. PIPA596574

Description

Immunogen sequence: GPPLGGGEGE AESADTMPFV MLTRKGNKQQ FKILNVPMSS QLAANHWNQQ QAEQEERMRM KKLTLDINER QEQEDYQEML QSLAQRPAPA NTNRERRPRY QHPKGAPNAD LIFKTGGRRR; Positive Samples: HT-29, Jurkat, HepG2, Mouse brain; Cellular Location: Cytoplasm, perinuclear region.

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.

Specifications

• Antigen: UPF2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UPF2
• Gene Alias: HUPF2; KIAA1408; Nonsense mRNA reducing factor 2; regulator of nonsense transcripts 2; RENT2; smg-3; smg-3 homolog, nonsense mediated mRNA decay factor; UPF2; UPF2 regulator of nonsense transcripts homolog (yeast); up-frameshift suppressor 2 homolog; yeast Upf2p homolog
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26019, 326622
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 1.17 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9HAU5
• Gene Symbols: UPF2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1272 of human UPF2 (NP_5421661).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov