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UPF3B Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501565791
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50-156-5791 10 μL
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Catalog No. 50-156-5791 Supplier Bethyl Laboratories, Inc Supplier No. A303689AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctionsThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Specifications

Antigen UPF3B
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene UPF3B
Gene Accession No. Q9BZI7
Gene Alias UPF3 regulator of nonsense transcripts homolog B (yeast), UPF3X, HUPF3B, MRXS14, RENT3B
Gene Symbols UPF3B
Host Species Rabbit
Immunogen Between 433 and 483
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 65109
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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