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UPF3B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. 501734040 Shop All Proteintech Group Inc Products
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50-173-4040 150 μL
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Catalog No. 50-173-4040 Supplier Proteintech Group Inc Supplier No. 233011AP150UL
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Description

Rabbit Polyclonal Antibody

UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Specifications

Antigen UPF3B
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.61 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene UPF3B
Gene Accession No. Q9BZI7
Gene Alias HUPF3B, hUpf3p X, MRXS14, RENT3B, UPF3B, UPF3X
Gene Symbols Upf3b
Host Species Rabbit
Immunogen UPF3B Fusion Protein Ag18568
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 313449, 65109, 68134
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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