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Tocris Bioscience™ uPSEM 792 hydrochloride

Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

Manufacturer:  Tocris Bioscience™ 6865/5

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Catalog No. 68-655


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Description

Description

uPSEM 792 hydrochloride is a ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (∽10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant.
Specifications

Specifications

98%
C14H15N3O.HCl
1-Methyl-7,8,9,10-tetrahydro-1 H-6,10-methanoazepino[4,5-g]quinoxalin-2(6 H)-one hydrochloride
5 mg
277.75
Pharmacologically Selective Effector Molecules/PSEM
2341841-08-3
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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