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Tocris Bioscience™ uPSEM 792 hydrochloride

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Quantity:
5 mg
25 mg
Description
uPSEM 792 hydrochloride is a ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (∽10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant.
Specifications
Specifications
Chemical Name or Material | 1-Methyl-7,8,9,10-tetrahydro-1 H-6,10-methanoazepino[4,5-g]quinoxalin-2(6 H)-one hydrochloride |
CAS | 2341841-08-3 |
Quantity | 5 mg |
Target | Pharmacologically Selective Effector Molecules/PSEM |
Molecular Formula | C14H15N3O.HCl |
Formula Weight | 277.75 |
Purity | 98% |
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