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  5. Tocris Bioscience™ uPSEM 817 tartrate

Tocris Bioscience™ uPSEM 817 tartrate
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Catalog No. 68665
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Catalog No. Quantity
68-665 5 mg
68-662-5 25 mg
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Catalog No. 68-665 Supplier Tocris Bioscience™ Supplier No. 6866/5
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Description

Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

uPSEM 817 tartrate is a selective ultrapotent PSEM (uPSEM) agonist for α7L131G,Q139L,Y217F-GlyR (PSAM4-GlyR) and PSAM4-5-HT3 chimeric ion channels (EC50 values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical neurons expressing PSAM4-GlyR in brain slices. Increases contralateral rotation in mice expressing PSAM4-GlyR unilaterally in the substantia nigra reticulata (LED 0.1 mg/kg).

Specifications

Chemical Name or Material 2-Propoxy-7,8,9,10-tetrahydro-6 H-6,10-methanoazepino[4,5-g]quinoxaline L-tartrate
CAS 2341833-14-3
Quantity 5 mg
Target Pharmacologically Selective Effector Molecules/PSEM
Molecular Formula C16H19N3O.C4H6O6
Formula Weight 419.43
Purity 98%
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