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Invitrogen™ RMP Polyclonal Antibody
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Catalog No. PIPA567193
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100 μL
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PIPA567193 100 μL
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Catalog No. PIPA567193 Supplier Invitrogen™ Supplier No. PA567193
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ILEEEPQENQK KLLPLSVTPE AFSGTVIEKE FVSPSLTPPP AIAHPALPTI PERKEVLLEA SEETGK Highest antigen sequence identity to the following orthologs - mouse 66%, rat 70%.

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. [Uniprot].
TRUSTED_SUSTAINABILITY

Specifications

Antigen RMP
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Uri1
Gene Accession No. O94763
Gene Alias C19orf2; C80913; FLJ10575; Nnx3; Ppp1r19; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; protein phosphatase 1, regulatory subunit 19; RMP; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein; Unconventional prefoldin RPB5 interactor; unconventional prefoldin RPB5 interactor 1; URI; Uri1; URI1 prefoldin-like chaperone; URI1, prefoldin like chaperone; URI1, prefoldin-like chaperone
Gene Symbols Uri1
Host Species Rabbit
Immunogen Recombinant Human RMP. Recombinant protein control fragment (Product #RP-107832).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8725
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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