Invitrogen™ RMP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA567193

Catalog No. PIPA567193

Description

Immunogen sequence: ILEEEPQENQK KLLPLSVTPE AFSGTVIEKE FVSPSLTPPP AIAHPALPTI PERKEVLLEA SEETGK Highest antigen sequence identity to the following orthologs - mouse 66%, rat 70%.

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. [Uniprot].

Specifications

• Antigen: RMP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Uri1
• Gene Alias: C19orf2; C80913; FLJ10575; Nnx3; Ppp1r19; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; protein phosphatase 1, regulatory subunit 19; RMP; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein; Unconventional prefoldin RPB5 interactor; unconventional prefoldin RPB5 interactor 1; URI; Uri1; URI1 prefoldin-like chaperone; URI1, prefoldin like chaperone; URI1, prefoldin-like chaperone
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8725
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O94763
• Gene Symbols: Uri1
• Immunogen: Recombinant Human RMP. Recombinant protein control fragment (Product #RP-107832).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG