Invitrogen™ Uromodulin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583658

Catalog No. PIPA583658

Description

Immunogen sequence: GYYVYNLTAP PECHLAYCTD PSSVEGTCEE CSIDEDCKSN NGRWHCQCKQ DFNITDISLL EHRLECGAND MKVSLGK.

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Specifications

• Antigen: Uromodulin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Umod
• Gene Alias: ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; Tamm-Horsfall urinary glycoprotein; THGP; THP; UMOD; Urehd1; urehr4; Urmodulin (Tamm-Horsfall protein); uromodulin; Uromodulin, secreted form; uromucoid; uromucoid uromucoid
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7369
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P07911
• Gene Symbols: Umod
• Immunogen: Recombinant protein corresponding to Human UMOD. Recombinant protein control fragment (Product #RP-98766).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG