URP2 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-3120	100 μL

Catalog No. 50-198-3120 Supplier Bioss Supplier No. BS13738R

Description

Rabbit Polyclonal Antibody

The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.

Specifications

• Antigen: URP2
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: Fermt3
• Gene Accession No.: Q86UX7
• Gene Alias: C79673; Fermitin family homolog 3; fermitin family homolog 3 (Drosophila); fermitin family member 3; Fermt3; KIND3; kindlin 3; Kindlin3; Kindlin-3; MGC10966; MIG-2; MIG2B; MIG2-like protein; RGD1310168; UNC-112 related protein 2; UNC112C; Unc-112-related protein 2; Urp2; URP2SF
• Gene Symbols: Fermt3
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human URP2.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 83706
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG