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USP11 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 102441AP150UL

Encompass_Preferred

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Catalog No. 50-172-6144


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Description

Description

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
Specifications

Specifications

USP11
Polyclonal
Unconjugated
USP11
Deubiquitinating enzyme 11, Ubiquitin thiolesterase 11, UHX1, USP11
Rabbit
Antigen Affinity Chromatography
RUO
8237
Antibody
IgG
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P51784
USP11
USP11 Fusion Protein Ag0296
150 μL
Primary
Human
Liquid
Safety and Handling

Safety and Handling

SDS
Documents
Product Certifications
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