Invitrogen™ USP16 Polyclonal Antibody

Catalog No.	Quantity
PIPA596452	100 μL

Catalog No. PIPA596452 Supplier Invitrogen™ Supplier No. PA596452

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGKKRTKGKT VPIDDSSETL EPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYVCD NEVQYCSSNQ LGQVVDYVRK QASITTPKPE KDNGNIELEN KKLEKESKNE QEREKKENMA KENPPMNSPC QITVKGLSNL GNTCFFNAVM QNLSQTPVLR ELLKEVKMSG TIVKIEPPDL ALTEPLEINL EPPGPLTLAM SQFLNEMQET KKGVVTPKEL; Positive Samples: COS-7, 293T, NIH/3T3, Mouse brain, Mouse heart, Mouse spleen, Rat brain; Cellular Location: Nucleus.

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Specifications

• Antigen: USP16
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.67 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene: USP16
• Gene Accession No.: Q2KJ09, Q99LG0, Q9Y5T5
• Gene Alias: 1200004E02Rik; 2810483I07Rik; 6330514E22Rik; Deubiquitinating enzyme 16; deubiquitinating enzyme 16 {ECO:0000255; HAMAP-Rule:MF_03062}; MSTP039; Ubiquitin carboxyl-terminal hydrolase 16; ubiquitin carboxyl-terminal hydrolase 16 {ECO:0000255; Ubiquitin carboxyl-terminal hydrolase 16-like protein; ubiquitin specific peptidase 16; ubiquitin specific protease 16; ubiquitin thioesterase 16; ubiquitin thioesterase 16 {ECO:0000255; ubiquitin thiolesterase 16; ubiquitin-processing protease UBP-M; ubiquitin-specific processing protease 16; ubiquitin-specific-processing protease 16; ubiquitin-specific-processing protease 16 {ECO:0000255; UBPM; UBP-M; USP16
• Gene Symbols: USP16
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human USP16 (NP_0010019921).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10600, 288306, 74112
• Target Species: Human, Mouse, Rat, Monkey
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov