Invitrogen™ USP19 Polyclonal Antibody

Catalog No.	Quantity
PIPA597239	100 μL

Catalog No. PIPA597239 Supplier Invitrogen™ Supplier No. PA597239

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGDPR KETGSRYVAQ AGLEPLASGD PSASASHAAG ITGSRHRTRL FFPSSSGSAS TPQEEQTKEG ACEDPHDLLA TPTPELLLDW RQSAEEVIVK LRVGVGPLQL EDVDAAFTDT DCVVRFAGGQ QWGGVFYAEI KSSCAKVQTR KGSLLHLTLP KKVPMLTWPS; Positive Samples: U-87MG, A-431, HeLa; Cellular Location: Endoplasmic reticulum membrane, Single-pass membrane protein.

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs), 1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Specifications

• Antigen: USP19
• Applications: ELISA, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.55 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: USP19
• Gene Accession No.: O94966, Q3UJD6
• Gene Alias: 8430421I07Rik; AI047774; Deubiquitinating enzyme 19; KIAA0891; Ubiquitin carboxyl-terminal hydrolase 19; ubiquitin specific peptidase 19; ubiquitin specific protease 19; ubiquitin thioesterase 19; ubiquitin thiolesterase 19; ubiquitin-specific processing protease 19; ubiquitin-specific-processing protease 19; Usp19; Zinc finger MYND domain-containing protein 9; Zmynd9
• Gene Symbols: USP19
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human USP19 (NP_0011860891).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10869, 71472
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG