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USP20 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA571898
Description
Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both ′Lys-48′- and ′Lys-63′-linked polyubiquitin chains.
Specifications
USP20 | |
Polyclonal | |
Unconjugated | |
USP20 | |
LSFR3A; VDU2; VHL-interacting deubiquitinating enzyme 2; deubiquitinating enzyme 20; hVDU2; pVHL-interacting deubiquitinating enzyme 2; ubiquitin carboxyl-terminal hydrolase 20; ubiquitin specific protease 20; ubiquitin thioesterase 20; ubiquitin thiolesterase 20; ubiquitin-sp | |
Rabbit | |
Protein A | |
RUO | |
10868, 74270 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
0.57 mg/mL | |
PBS with 0.09% sodium azide | |
Q8C6M1, Q9Y2K6 | |
USP20 | |
KLH conjugated synthetic peptide between 310-339 amino acids from the Central region of human USP20 | |
400 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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