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USP20 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA571898

Catalog No. PIPA571898


Description

Description

Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both ′Lys-48′- and ′Lys-63′-linked polyubiquitin chains.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

USP20
Polyclonal
Unconjugated
USP20
LSFR3A; VDU2; VHL-interacting deubiquitinating enzyme 2; deubiquitinating enzyme 20; hVDU2; pVHL-interacting deubiquitinating enzyme 2; ubiquitin carboxyl-terminal hydrolase 20; ubiquitin specific protease 20; ubiquitin thioesterase 20; ubiquitin thiolesterase 20; ubiquitin-sp
Rabbit
Protein A
RUO
10868, 74270
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
0.57 mg/mL
PBS with 0.09% sodium azide
Q8C6M1, Q9Y2K6
USP20
KLH conjugated synthetic peptide between 310-339 amino acids from the Central region of human USP20
400 μL
Primary
Human, Mouse
Antibody
IgG
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