Invitrogen™ USP3 Polyclonal Antibody

Catalog No.	Quantity
PIPA5111505	100 μL

Catalog No. PIPA5111505 Supplier Invitrogen™ Supplier No. PA5111505

Description

Rabbit Polyclonal Antibody

Immunogen sequence: SSSVCIAPDS AKFPNGSPSS WCCSVCRSNK SPWVCLTCSS VHCGRYVNGH AKKHYEDAQV PLTNHKKSEK QDKVQHTVCM DCSS Highest antigen sequence indentity to the following orthologs: Rat - 88%, Mouse - 94%.

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Specifications

• Antigen: USP3
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: USP3
• Gene Accession No.: Q9Y6I4
• Gene Alias: AA409661; BC017156; Deubiquitinating enzyme 3; SIH003; Ubiquitin carboxyl-terminal hydrolase 3; ubiquitin specific peptidase 3; ubiquitin specific protease 3; ubiquitin thioesterase 3; ubiquitin thiolesterase 3; ubiquitin-specific-processing protease 3; UBP; Usp3
• Gene Symbols: USP3
• Host Species: Rabbit
• Immunogen: Recombinant Protein corresonding to Human USP3. Recombinant protein control fragment (Product #RP-107011).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9960
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov