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USP33 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501572214
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50-157-2214 10 μL
50-157-2213 100 μL
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Catalog No. 50-157-2214 Supplier Bethyl Laboratories, Inc Supplier No. IHC00508T
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Panda, Orangutan, Monkey, Gorilla

Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both ′Lys-48′-and ′Lys-63′-linked polyubiquitin chains.

Specifications

Antigen USP33
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene USP33
Gene Accession No. Q8R5K2, Q8TEY7
Gene Alias deubiquitinating enzyme 33, hVDU1, KIAA1097, pVHL-interacting deubiquitinating enzyme 1, ubiquitin specific protease 33, ubiquitin thioesterase 33, ubiquitin thiolesterase 33, ubiquitin-specific-processing protease 33, VDU1, VHL-interacting deubiquitinating enzyme 1
Gene Symbols USP33
Host Species Rabbit
Immunogen Between 900 and C-term
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170822, 23032
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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