Invitrogen™ USP35 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563086

Catalog No. PIPA563086

Description

Immunogen sequence: PPERCRRRRL GSVMRPTEDI TARELPPPTS AQGPGRVGPR RQRKHCITED TPPTSLYIEG LDSKEAGGQS SQEERIERE Highest antigen sequence identity to the following orthologs: Mouse - 53%, Rat - 58%.

p73 protein is a member of the p53 family of proteins. The tumor-suppressor protein p53 exhibits sequence specific DNA-binding, directly interacts with various cellular and viral proteins, and induces cell cycle arrest in response to DNA damage. In response to signals generated by a variety of genotoxic stresses, e.g, UV irradiation or DNA damage, p53 is expressed and undergoes post-translational modification that results in its accumulation in the nucleus. Activation of p53 leads to cell cycle arrest and in some cases to apoptosis, resulting in the inability of genetically damaged cells to proliferate. Thus, the p53-dependent pathways help to maintain genomic stability by eliminating damaged cells. The accumulation of high levels of p53 is a potential marker for malignancy.

Specifications

• Antigen: USP35
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: USP35
• Gene Alias: Deubiquitinating enzyme 35; Gm1088; Gm493; KIAA1372; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 35; RGD1565984; Ubiquitin carboxyl-terminal hydrolase 35; ubiquitin specific peptidase 35; ubiquitin specific protease 35; ubiquitin thioesterase 35; ubiquitin thiolesterase 35; ubiquitin-specific-processing protease 35; USP34; USP35
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57558
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.9 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9P2H5
• Gene Symbols: USP35
• Immunogen: Recombinant protein corresponding to Human USP35. Recombinant protein control fragment (Product #RP-101228).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG