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Invitrogen™ USP37 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA531266
Description
Recommended positive controls: 293T. Predicted reactivity: Mouse (87%), Dog (91%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). [UniProt].
Specifications
USP37 | |
Polyclonal | |
Unconjugated | |
Usp37 | |
4932415L06Rik; C330008N13Rik; Deubiquitinating enzyme 37; Kiaa1594; tmp_locus_50; ubiquitin carboxyl-terminal hydrolase 37; ubiquitin specific peptidase 37; ubiquitin specific peptidase 37-like; ubiquitin specific protease 37; ubiquitin thioesterase 37; ubiquitin thiolesterase 37; ubiquitin-specific-processing protease 37; USP37 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
57695 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
1 mg/mL | |
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7 | |
Q86T82 | |
Usp37 | |
Recombinant fragment corresponding to a region within amino acids 617 and 892 of Human USP37. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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