Invitrogen™ USP5 Monoclonal Antibody (1340CT704.170.140)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA537650

Catalog No. PIMA537650

Description

USP5 Monoclonal Antibody for Western Blot

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in unanchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Specifications

• Antigen: USP5
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: USP5
• Gene Alias: AA407472; deubiquitinating enzyme 5; EGK_03293; Isopeptidase T; Isot; ISOT-1; testicular tissue protein Li 218; ubiquitin carboxy terminal hydrolase T; ubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific peptidase 5; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5; ubiquitin specific protease 5 (isopeptidase T); ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); ubiquitin-specific-processing protease 5; Ucht; Usp5
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 22225, 297593, 8078
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Clone: 1340CT704.170.140
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P45974, P56399
• Gene Symbols: USP5
• Immunogen: Recombinant protein from the human region of human USP5.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1 κ

Safety and Handling

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