USP5 Monoclonal Antibody (OTI1A8), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA501312

Catalog No. 50-167-2458

Description

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Specifications

• Antigen: USP5
• Classification: Monoclonal
• Concentration: 0.73 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P45974
• Gene Symbols: USP5
• Immunogen: Full length human recombit protein of human USP5 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1A8
• Conjugate: Unconjugated
• Gene: USP5
• Gene Alias: ISOT
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8078
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid