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USP5 Monoclonal Antibody (OTI1A8), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA501312

Encompass_Preferred

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Catalog No. 50-167-2458


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Description

Description

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Specifications

Specifications

USP5
Monoclonal
0.73 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P45974
USP5
Full length human recombit protein of human USP5 produced in HEK293T cell.
100 μL
Primary
Human
Antibody
IgG1
Immunohistochemistry (Paraffin), Western Blot
OTI1A8
Unconjugated
USP5
ISOT
Mouse
Affinity Chromatography
RUO
8078
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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