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USP5 Monoclonal Antibody (OTI1F8), TrueMAB™, OriGene
SDP

Catalog No. 501672435
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50-167-2435 100 μL
50-254-2408 30 μL
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Catalog No. 50-167-2435 Supplier OriGene Supplier No. TA501287
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Description

Mouse Monoclonal Antibody

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Specifications

Antigen USP5
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1F8
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene USP5
Gene Accession No. P45974
Gene Alias ISOT
Gene Symbols USP5
Host Species Mouse
Immunogen Full length human recombit protein of human USP5 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 297593, 486718, 8078
Target Species Canine, Human, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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