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Invitrogen™ USP5 Polyclonal Antibody
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Catalog No. PIPA552341
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100 μL
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PIPA552341 100 μL
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Catalog No. PIPA552341 Supplier Invitrogen™ Supplier No. PA552341
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YVDKLEKIFQ NAPTDPTQDF STQVAKLGHG LLSGEYSKPV PESGDGERVP EQKEVQDGIA PRMFKALIGK GHPEFSTNRQ QDAQEFFLHL INMVERNCRS SENPNEVF Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in unanchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
TRUSTED_SUSTAINABILITY

Specifications

Antigen USP5
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene USP5
Gene Accession No. P45974, P56399
Gene Alias AA407472; deubiquitinating enzyme 5; EGK_03293; Isopeptidase T; Isot; ISOT-1; testicular tissue protein Li 218; ubiquitin carboxy terminal hydrolase T; ubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific peptidase 5; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5; ubiquitin specific protease 5 (isopeptidase T); ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); ubiquitin-specific-processing protease 5; Ucht; Usp5
Gene Symbols USP5
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human USP5. Recombinant protein control fragment (Product #RP-89253).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22225, 297593, 8078
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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