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Invitrogen™ USP8 Polyclonal Antibody
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Catalog No. PIPA527947
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100 μL
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PIPA527947 100 μL
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Catalog No. PIPA527947 Supplier Invitrogen™ Supplier No. PA527947
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: H1299, HCT116. Predicted reactivity: Rhesus Monkey (95%), Bovine (83%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell energy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structure/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.
TRUSTED_SUSTAINABILITY

Specifications

Antigen USP8
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene USP8
Gene Accession No. P40818, Q80U87
Gene Alias AI574262; AW557536; Deubiquitinating enzyme 8; hUBPy; HumORF8; Kiaa0055; mKIAA0055; mUBPy; putative deubiquitinating enzyme; SPG59; Ubiquitin carboxyl-terminal hydrolase 8; ubiquitin isopeptidase Y; ubiquitin specific peptidase 8; ubiquitin specific protease 8; ubiquitin thioesterase 8; ubiquitin thiolesterase 8; ubiquitin-specific-processing protease 8; Ubpy; USP8
Gene Symbols USP8
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human USP8. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84092, 9101
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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