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Invitrogen™ USP8 Polyclonal Antibody
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Catalog No. PIPA5111308
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100 μL
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PIPA5111308 100 μL
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Catalog No. PIPA5111308 Supplier Invitrogen™ Supplier No. PA5111308
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KRPDFKQQQD YFHSILGPGN IKKAVEEAER LSESLKLRYE EAEVRKKLEE KDRQEEAQRL QQKRQETGRE DGGTLAKGSL ENVLDSKDKT QKSNGEKNEK CETKEKGAIT AKELYTMMTD Highest antigen sequence indentity to the following orthologs: Rat - 76%, Mouse - 78%.

USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell energy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structure/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.
TRUSTED_SUSTAINABILITY

Specifications

Antigen USP8
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.20 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene USP8
Gene Accession No. P40818
Gene Alias AI574262; AW557536; Deubiquitinating enzyme 8; hUBPy; HumORF8; Kiaa0055; mKIAA0055; mUBPy; putative deubiquitinating enzyme; SPG59; Ubiquitin carboxyl-terminal hydrolase 8; ubiquitin isopeptidase Y; ubiquitin specific peptidase 8; ubiquitin specific protease 8; ubiquitin thioesterase 8; ubiquitin thiolesterase 8; ubiquitin-specific-processing protease 8; Ubpy; USP8
Gene Symbols USP8
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human USP8. Recombinant protein control fragment (Product #RP-106263).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9101
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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