Invitrogen™ UTRN Polyclonal Antibody

Catalog No.	Quantity
PIPA553873	100 μL

Catalog No. PIPA553873 Supplier Invitrogen™ Supplier No. PA553873

Description

Rabbit Polyclonal Antibody

Immunogen sequence: GELDKQLTTY LTDRIDAFQV PQEAQKIQAE ISAHELTLEE LRRNMRSQPL TSPESRTARG GSQMDVLQRK LREVSTKFQL FQKPANFEQR MLDCKRVLDG VKAELHVLDV KDVDPDVIQT HLDKCMKLYK TLSEVKLEVE TVI Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

The UTRN gene encodes the utrophin protein, which is closely related to dystrophin in structure and function, playing a crucial role in maintaining the integrity of muscle fiber membranes. Located on chromosome 6, utrophin is expressed widely in fetal tissues but is replaced by dystrophin in mature muscle fibers; however, it remains present in adult tissues such as the neuromuscular junction and blood vessels. Utrophin's primary role is to stabilize the cytoskeleton and membrane linkages, forming part of the protein complex responsible for structural support in muscle cells. This protein has garnered significant attention in the context of muscular dystrophies, particularly Duchenne Muscular Dystrophy (DMD), where utrophin upregulation is considered a potential therapeutic strategy to compensate for the lack of functional dystrophin. It helps to ameliorate muscle pathology by mimicking the stabilizing effects of dystrophin, thus preserving muscle function and reducing damage. Research on enhancing utrophin expression is ongoing, aiming to provide an effective treatment modality for DMD and other dystrophin-associated disorders.

Specifications

• Antigen: UTRN
• Applications: Immunocytochemistry, Immunohistochemistry
• Classification: Polyclonal
• Concentration: 0.10 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: UTRN
• Gene Accession No.: P46939
• Gene Alias: DMDL; DRP; DRP1; DRP-1; Dystrophin-related protein 1; UTRN; Utrophin
• Gene Symbols: UTRN
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human UTRN. Recombinant protein control fragment (Product #RP-101029).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7402
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG