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Invitrogen™ UVRAG Polyclonal Antibody
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Catalog No. PIPA577811
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100 μg
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Catalog No. Quantity
PIPA577811 100 μg
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Catalog No. PIPA577811 Supplier Invitrogen™ Supplier No. PA577811
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Description

Rabbit Polyclonal Antibody

A 1:1,000 dilution of PA5-77811 was sufficient for detection of UVRAG on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody. Predicted molecular weight at approximately 78.1kDa. Observed molecular weights in the 75-90kDa range.

UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain. It interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenicity of human colon cancer cells. The gene for UVRAG protein is localized on human chromosome 11q13. 5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. The gene has been extremely well conserved during evolution, implying an important role for this gene product in cell metabolism. Chromosomal aberrations involving this gene are associated with left-right axis malformation, and mutations in this gene have been associated with colon cancer. The protein is highly expressed in human brain, lung, kidney and liver.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UVRAG
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
Gene Uvrag
Gene Accession No. Q8K245, Q9P2Y5
Gene Alias 9530039D02Rik; AI648770; BB124205; beclin 1 binding protein; DHTX; disrupted in heterotaxy; hypothetical protein; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance-associated gene protein; UV radiation resistance-associated protein; UVRAG; Uvrag1; Uvragl; VPS38
Gene Symbols Uvrag
Host Species Rabbit
Immunogen Synthetic peptide from the mid-protein of human UVRAG (C-SRSTIKDNINDK) (aa 391-402).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 308846, 7405, 78610
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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